The Neurosciences
Neuroscience is a rapidly evolving research field, crucial for understanding the human brain’s functioning and its impact on behavior, emotions, learning, and mental health. We discuss recent scientific advances and potential clinical applications with Professor Tommaso Pizzorusso, Professor of Neurobiology at the Scuola Normale Superiore in Pisa and Leader of Spoke 8 of THE, through projects developed within the Tuscany Health Ecosystem (THE).
Intelligent neuroprosthetics. A significant area of research involves the development of advanced neuroprosthetics, primarily by the Sant’Anna School. These prostheses can restore tactile and thermal perceptions and integrate with the nervous system, simulating a natural sensation. Thanks to these technologies, people with amputations can regain bodily sensations through electrical impulses that stimulate nerves, improving motor integration and functionality.
eurodegenerative diseases and Alzheimer’s treatments. In Spoke 8, research is conducted on neurodegenerative diseases such as Alzheimer’s. In collaboration with other institutions, innovative multi-target molecules are being developed that can act on multiple proteins simultaneously, thus enhancing treatment efficacy. This “Swiss Army knife” approach offers a more integrated action than traditional treatments.
Nano-antibodies and Artificial Intelligence for brain tumors. Research at Spoke 8 also explores the use of nano-antibodies in combination with artificial intelligence for brain tumor treatments. Nano-antibodies, due to their small size and tissue penetration ability, can more precisely target tumor cells, while AI aids in developing new drugs by analyzing complex data to personalize treatments based on the specific structure of each patient’s tumor.
Neurodevelopmental Disorders and Gene Therapy. Another significant area of research is neurodevelopmental disorders, many of which have genetic origins and, while individually rare, are collectively common. The research aims to develop more precise and advanced diagnostic indicators, such as imaging tools, to evaluate the progression of these disorders in children. Additionally, gene therapies that directly target genetic causes are being explored, with pilot studies on disorders like creatine deficiency and international collaborations, including with the University of Edinburgh and Neurogenics in the United States for Rett syndrome. These collaborations are crucial for acquiring the expertise needed for eventual clinical applications, aiming to develop therapies that address the root genetic causes rather than merely managing symptoms.
